Potent protective effect of apricot and beta-carotene on methotrexate-induced intestinal oxidative damage in rats

VARDI N., PARLAKPINAR H., OZTURK F., ATEŞ B., GÜL M., CETIN A., ...More

FOOD AND CHEMICAL TOXICOLOGY, vol.46, no.9, pp.3015-3022, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.1016/j.fct.2008.05.039
  • Journal Name: FOOD AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3015-3022
  • Keywords: apricot, beta-carotene, oxidative damage, methotrexate, ANTIOXIDANT ENZYMES, IN-VIVO, STRESS, LYCOPENE, INFLAMMATION, FLAVONOIDS, DECREASE, INJURY
  • Inonu University Affiliated: Yes

Abstract

Several studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the small intestine. Many agents have been tried experimentally to reduce or inhibit the oxidative stress. To our knowledge, there is no study about apricot consumption on the MTX-induced damage in the small intestine. The aim of this study was to determine the possible protective effects of apricot and beta-carotene on MTX-induced intestinal damage in rats. The rats were randomly divided into seven groups as follows; I-control group; H-apricot group; III-beta-carotene group; IV-MTX group: V-apricot + MTX group; VI-beta-carotene + MTX group and VII-apricot + beta-carotene + MTX group.