Potent protective effect of apricot and beta-carotene on methotrexate-induced intestinal oxidative damage in rats

VARDI N., PARLAKPINAR H., OZTURK F., ATEŞ B., GÜL M., CETIN A., ...Daha Fazla

FOOD AND CHEMICAL TOXICOLOGY, cilt.46, sa.9, ss.3015-3022, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.fct.2008.05.039
  • Dergi Adı: FOOD AND CHEMICAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3015-3022
  • Anahtar Kelimeler: apricot, beta-carotene, oxidative damage, methotrexate, ANTIOXIDANT ENZYMES, IN-VIVO, STRESS, LYCOPENE, INFLAMMATION, FLAVONOIDS, DECREASE, INJURY
  • İnönü Üniversitesi Adresli: Evet

Özet

Several studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the small intestine. Many agents have been tried experimentally to reduce or inhibit the oxidative stress. To our knowledge, there is no study about apricot consumption on the MTX-induced damage in the small intestine. The aim of this study was to determine the possible protective effects of apricot and beta-carotene on MTX-induced intestinal damage in rats. The rats were randomly divided into seven groups as follows; I-control group; H-apricot group; III-beta-carotene group; IV-MTX group: V-apricot + MTX group; VI-beta-carotene + MTX group and VII-apricot + beta-carotene + MTX group.