Resveratrol, a red wine constituent polyphenol, protects gastric tissue against the oxidative stress in cholestatic rats

Kirimlioglu V., Ara C., Yilmaz M., Ozgor D., Isik B., Sogutlu G., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.51, no.2, pp.298-302, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1007/s10620-006-3128-9
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.298-302
  • Keywords: resveratrol, biliary cirrhosis, malondialdehyde, reduced glutathione, nitric oxide, NITRIC-OXIDE SYNTHASE, PORTAL-HYPERTENSIVE-RATS, OBSTRUCTIVE-JAUNDICE, CIRRHOTIC RATS, DAMAGE, GLUTATHIONE, MUCOSA, CELLS, EXPRESSION, MECHANISM
  • Inonu University Affiliated: Yes

Abstract

This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis.