Rat hipokampusunde akrilamidin oluşturduğu toksik etkiye karşı zerdeçalın koruyucu etkisinin mikroanatomik olarak incelenmesi


Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: İnönü Üniversitesi, Sağlık Bilimleri Enstitüsü, Anatomi Yüksek Lisans, Türkiye

Tezin Onay Tarihi: 2020

Tezin Dili: Türkçe

Öğrenci: Merve ASLANÖZ

Danışman: Davut Özbağ

Özet:

ABSTRACT

Purpose: Previous studies have indicated that cephalometric changes may occur in patients with chronic sinusitis and septum deviation. In this study, it was aimed to determine how the cephalometric measurements of healthy individuals to be used as chronic sinusitis, septum deviation and control group will change with CT measurements.

Material and Method: The study was carried out in Department of Anatomy and the Radiology Department of İnönü University Turgut Özal Medical Center Training and Research Hospital. Our study was evaluated retrospectively using paranasal computed tomography images taken from a total of 153 patients (77 females, 76 males) aged between 20 and 51 years. The evaluation was made using the Sectra program. Volume measurements were made using Myrian software, a special volume measurement program. A total of 15 cephalometric parameters were evaluated on each CT image included in the study. The compliance of the data to normal distribution was examined with the Kolmogorov Smirnov test.The Kruskall Wallis H test was applied to the data to compare the same age groups of patients with chronic sinusitis, septum deviation and the control group. Mann Whitney U test was applied to the data to compare patients within the same group.

Results: When we compare male and female patients with chronic sinusitis, according to the analysis result, Sna-EgT Snp-EgT, Sna-H, Snp-H, SMVÇ-R, MSM parameters; When we compare male and female patients with septum deviation, according to the analysis result, Sna-Snp, Sna-EgT, Snp-EgT, Sna-H, Snp-H, SMH-R SMH-L SMVÇ-R, SMTÇ-L, SMVÇ-L parameters and control when we compared the men and women in the group, it was found that there was a significant difference in the parameters Sna-EgT, Snp-EgT, Sna-H, Snp-H according to the analysis result (p <0.05).When we compared the three men between the ages of 20-35 and between the ages of 36-51 in the chronic sinusitis, septum deviation and control group, a significant difference was found in the MPA-R parameter in men aged 20-35 (p <0.05). Significant differences were found in SMH-L, SMTD-L, SMVD-L, MPA-R parameters in men aged 36-51 years (p <0.05). When we compared the three women between the ages of 20-35 and between the ages of 36-51 in the chronic sinusitis, septum deviation and control group, a significant difference was found in the SMVD-L parameter in women aged 36-51 (p <0.05).

Conclusion: In this study, we think that cephalometric measurement results obtained from patients with chronic sinusitis and septum deviation may contribute to physicians in anatomical and morphological evaluations in diagnosis, treatment and surgical operations.

Keywords: Chronic sinusitis, septum deviation, cephalometry, computed tomography