Epigenetic mechanisms in the development of psychiatric disorders


EROL D., Elyas Z., ÜNAL S.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.20, ss.109-114, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 1
  • Basım Tarihi: 2010
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Sayfa Sayıları: ss.109-114

Özet

Epigenetics is defined as the study of heritable changes of gene function that occur without a change in the nucleotide sequence of DNA. Aberrant epigenetic mechanisms have been directly implicated in certain human diseases. There is much evidence that epigenetic regulation is involved in neurogenesis, neuronal plasticity, learning and memory, and in psychiatric disorders such as depression, addiction, schizophrenia, and cognitive dysfunction. In this review, the epigenetics mechanisms and their role in the development of psychiatric disorders were discussed.