Subacute sclerosing panencephalitis with fulminating course: Follow-up magnetic resonance spectroscopy (MRS) findings

Alkan A., Kutlu R., Sigirci A., Aslan M., Sarac K., Yakinci C.

JOURNAL OF CHILD NEUROLOGY, cilt.19, ss.233-238, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 3
  • Basım Tarihi: 2004
  • Sayfa Sayıları: ss.233-238


The fulminating form of subacute sclerosing panencephalitis is an extremely rare condition. Imaging findings are usually not correlated with clinical staging. We describe a 4-year-old girl with severe neuronal loss, demyelination, and gliosis in subcortical white matter by magnetic resonance spectroscopic examination even though she was diagnosed as clinical stage II. In 2 months' time, her clinical status worsened significantly. Follow-up magnetic resonance spectroscopy revealed findings that were consistent with clinical status. It is our opinion that magnetic resonance spectroscopy could demonstrate a rapidly progressive fulminating course of subacute sclerosing panencephalitis even in the early clinical stages.