Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer's Type Dementia?

CUMURCU T., DORAK F., CUMURCU B. E., Erbay L. G., OZSOY E.

SEMINARS IN OPHTHALMOLOGY, cilt.28, sa.4, ss.224-229, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/08820538.2013.793726
  • Dergi Adı: SEMINARS IN OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.224-229
  • Anahtar Kelimeler: Alzheimer's disease, cataract, dementia, glaucoma, pseudoexfoliation syndrome, AMYLOID PRECURSOR PROTEIN, RISK-FACTOR, COGNITIVE IMPAIRMENT, EXFOLIATION SYNDROME, DISEASE, GLAUCOMA, HOMOCYSTEINE, BINDING, PEPTIDE, COPPER
  • İnönü Üniversitesi Adresli: Evet

Özet

Purpose: To investigate the frequency of Alzheimer-related dementia in patients with pseudoexfoliation syndrome (PEX). Methods: Sixty-seven patients with PEX and 67 age-, gender-, and educational-background-matched control subjects were compared for the presence of Alzheimer-related dementia according to DSM-IV-TR. The effects of cataract, glaucoma, additional ocular and systemic disease on the dementia incidence were also evaluated in patients with PEX and the control group. Results: The frequency of Alzheimer-related dementia was higher in patients with PEX (p = 0.0001). The frequency of dementia in patients who had cataract was higher than in patients without cataract (p = 0.003). There was also an association between additional ocular disease and dementia (p < 0.05). However, there was no association between systemic disease and dementia (p > 0.05). Furthermore, there was no difference for the frequency of dementia between patients who had glaucoma or not among patients with PEX (p = 0.953). Conclusion: The increased frequency of Alzheimer-related dementia in patients with PEX is important and a possible association between PEX and Alzheimer's disease could be present.