Effect of resveratrol in experimental osteoarthritis in rabbits

Elmali N., Esenkaya I., Harma A., Ertem K., Turkoz Y., Mizrak B.

INFLAMMATION RESEARCH, vol.54, no.4, pp.158-162, 2005 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1007/s00011-004-1341-6
  • Journal Name: INFLAMMATION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.158-162
  • Keywords: resveratrol, cartilage, osteoarthritis, NF-kappa B, COX-2, NF-KAPPA-B, TRANSCRIPTION FACTOR, ACTIVATION, WINE, INHIBITION, MODEL, INFLAMMATION, ABSORPTION, APOPTOSIS, CARTILAGE
  • Inonu University Affiliated: Yes

Abstract

Objective: Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B ( NF-kappa B). Resveratrol also inhibits COX-2 gene expression and enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits.