Effect of resveratrol in experimental osteoarthritis in rabbits
INFLAMMATION RESEARCH, cilt.54, sa.4, ss.158-162, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1007/s00011-004-1341-6
- Dergi Adı: INFLAMMATION RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.158-162
- Anahtar Kelimeler: resveratrol, cartilage, osteoarthritis, NF-kappa B, COX-2, NF-KAPPA-B, TRANSCRIPTION FACTOR, ACTIVATION, WINE, INHIBITION, MODEL, INFLAMMATION, ABSORPTION, APOPTOSIS, CARTILAGE
- İnönü Üniversitesi Adresli: Evet
Özet
Objective: Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B ( NF-kappa B). Resveratrol also inhibits COX-2 gene expression and enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits.