N-Heterocyclic Carbenes: Useful Ligands for the Palladium-Catalysed Direct C5 Arylation of Heteroaromatics with Aryl Bromides or Electron-Deficient Aryl Chlorides

ÖZDEMİR İ., GÖK Y., Ozeroglu O., KALOĞLU M., DOUCET H., BRUNEAU C.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, sa.12, ss.1798-1805, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: Sayı: 12
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/ejic.200901195
  • Dergi Adı: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1798-1805
  • Anahtar Kelimeler: Aryl halides, Atom economy, C-H activation, Carbenes, Heteroaromatics, Palladium, CROSS-COUPLING REACTIONS, DIRECT C-5 ARYLATION, H BOND ARYLATION, ROOM-TEMPERATURE, PD, COMPLEXES, THIAZOLES, FUNCTIONALIZATION, DERIVATIVES, 1,2,3-TRIAZOLES
  • İnönü Üniversitesi Adresli: Evet

Özet

New Pd-N-heterocyclic carbene complexes have been prepared and employed for palladium-catalysed direct arylation of heteroaromatic derivatives by using aryl halides. These catalyst precursors promote the coupling of challenging aryl halides such as deactivated or congested aryl bromides and also activated aryl chlorides. This procedure employs only 1 mol-% of an air-stable palladium complex. This is a practical advantage over the procedures that employ palladium attached to air-sensitive phosphane ligands, which are often used to promote the coupling of such aryl halides.