Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates


Panda S. S. , Ibrahim M. A. , KÜÇÜKBAY H. , Meyers M. J. , Sverdrup F. M. , El-Feky S. A. , ...Daha Fazla

CHEMICAL BIOLOGY & DRUG DESIGN, cilt.82, ss.361-366, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1111/cbdd.12134
  • Dergi Adı: CHEMICAL BIOLOGY & DRUG DESIGN
  • Sayfa Sayıları: ss.361-366

Özet

Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.