Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates

Panda, Siva; Ibrahim, Mohamed; KÜÇÜKBAY, HASAN; Meyers, Marvin; Sverdrup, Francis; El-Feky, Said; Katritzky, Alan

doi:10.1111/cbdd.12134

Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates

Panda S. S., Ibrahim M. A., KÜÇÜKBAY H., Meyers M. J., Sverdrup F. M., El-Feky S. A., ...Daha Fazla

CHEMICAL BIOLOGY & DRUG DESIGN, cilt.82, sa.4, ss.361-366, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 82 Sayı: 4
Basım Tarihi: 2013
Doi Numarası: 10.1111/cbdd.12134
Dergi Adı: CHEMICAL BIOLOGY & DRUG DESIGN
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.361-366
Anahtar Kelimeler: amino acid, chemical biology, drug design, peptide, TRYPTOPHAN, RESPONSES
İnönü Üniversitesi Adresli: Evet

Özet

Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.