Effects of Recombinant Activated Protein C Derived From Drotrecogin-Alpha on Bleomycin-Induced Pulmonary Fibrosis in Rats Compared with Methyl-Prednisolone
TURKISH THORACIC JOURNAL, cilt.14, sa.2, ss.48-52, 2013 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.5152/ttd.2013.10
- Dergi Adı: TURKISH THORACIC JOURNAL
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.48-52
- Anahtar Kelimeler: Bleomycin, pulmonary fibrosis, recombinant activated protein C, methyl-prednisolone, rat
- İnönü Üniversitesi Adresli: Evet
Özet
OBJECTIVE: In this study, we aimed to test the preventive effects of intraperitoneally administered drotrecogin alpha which is derived from activated protein C (APC), on bleomycin-induced pulmonary fibrosis in rats, and to compare the effects of APC with the effects of methyl-prednisolone, a traditional therapy.