Use of tetrahydropyridinium salts for highly efficient palladium-catalyzed cross-coupling reactions of aryl bromides and chlorides


Ozdemir I. , DEMIR S., CETINKAYA B.

TETRAHEDRON, cilt.61, ss.9791-9798, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 61 Konu: 41
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tet.2005.06.064
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.9791-9798

Özet

New, sterically demanding 1,3-dialkyl-3,4,5,6-tetrahydropyrimidinium salts (2) as NHC precursors have been synthesized and characterized. These salts, in combination with palladium acetate, provided active catalysts for the cross-coupling of aryl chlorides and bromides under mild conditions. The catalytic system was applied to the Heck, Suzuki and benzaldehyde (Kumada) coupling reactions. Catalyst activity was found to be influenced by the presence of a methoxy group on the ring of the p-position of benzyl substituent of the ligand precursor. (c) 2005 Elsevier Ltd. All rights reserved.