Oxidant/antioxidant parameters and their relationship with chemotherapy in Hodgkin's lymphoma

Kaya E., Keskin L., Aydogdu I., Kuku I., Bayraktar N., Erkut M.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.33, sa.6, ss.687-692, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1177/147323000503300611
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.687-692
  • Anahtar Kelimeler: ABVD, cisplatin, cancer chemotherapy, oxidant, antioxidant free radicals, Hodgkin's lymphoma, spectrophotometry, spectrofluorometry, OXIDATIVE STRESS, CYTOTOXICITY, ACID
  • İnönü Üniversitesi Adresli: Evet

Özet

This study investigated changing levels of serum oxidant/antioxidant with chemotherapy and their relation to treatment in 34 Hodgkin's lymphoma patients. The patient population consisted of 19 males and 15 females. Mean age was 30.41 12.08 years. All patients received the adriamycin, bleomycin, vincristine and dexamethasone (ABVD) treatment protocol. Blood samples were taken before treatment, and on days 1 and 7 during treatment for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA), nitric oxide (NO) and enzyme activities. After ABVD treatment, mean free radical levels were increased and antioxidant levels were significantly decreased in the serum. ABVD treatment results in an increase of free radical levels and a decrease of antioxidant levels in the serum of patients with Hodgkin's lymphoma.