Effect of receiver shape and volume on the Alzheimer disease for molecular communication via diffusion

IŞIK İ., Yilmaz H. B., Demirkol I., TAĞLUK M. E.

IET NANOBIOTECHNOLOGY, cilt.14, sa.7, ss.602-608, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1049/iet-nbt.2019.0300
  • Dergi Adı: IET NANOBIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, Communication Abstracts, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.602-608
  • Anahtar Kelimeler: diseases, molecular biophysics, neurophysiology, probability, receiver shape, Alzheimer disease, molecular communication, nanodevices, molecular interaction, smart medicine, neuronal communication, MC systems, high signal level, low-signal level, topological parameters, MC-based system, nanomedicine, cubic receiver model, correct reception ratio, molecular signal, cubic model, spherical model, topological system parameters, CUBIC MEMBRANE-STRUCTURE, MITOCHONDRIA
  • İnönü Üniversitesi Adresli: Evet

Özet

Nano-devices are featured to communicate via molecular interaction, the so-called molecular communication (MC). In MC systems, the information is carried by molecules where the amount of molecules constitutes the level of the signal. In this study, an MC-based system was analysed with different receiver topology and related parameters, such as size, shape, and orientation of receptors on the receiver. Also in the concept of nano-medicine, the effect of amyloid-beta (A(beta)), which is believed as the main cause of Alzheimer disease, on the successful reception ratio of molecules with the proposed receiver models was investigated. It was demonstrated that the cubic receiver model is superior to sphere one in terms of the correct reception ratio of the molecular signal. A cubic model where its edge (not rotated around the centre) is placed across the transmitter demonstrated a better performance in reducing the effect of A(beta) as compared to the sphere model while a cubic model where its corner (rotated around the centre) is placed across the transmitter demonstrated a worse performance than the spherical model. From this expression, it may be concluded that with the adjustment of topological system parameters the probability of successful reception ratio in MC may be possible.