Investigation of the effect of lacosamide on renal function: A 5-Year retrospective cohort study


ADIGÜZEL A.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.13, pp.11-15, 2022 (ESCI)

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2022
  • Doi Number: 10.4328/acam.21059
  • Journal Name: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.11-15
  • Keywords: Lacosamide, Antiepileptic Drugs, GFR, Sodium Channel Blocker, Seizure, REFRACTORY EPILEPSY, TOLERABILITY, SAFETY, RISK
  • Inonu University Affiliated: Yes

Abstract

Aim: Lacosamide, a third-generation antiepileptic drug, is used as adjunctive treatment of partial-onset seizures. It is mainly eliminated through the kidneys. The drug acts by enhancing the slow inactivation of voltage-gated sodium channels. The aim of this study was to investigate the long-term effects of lacosamide on renal function.