An innovation in stem cell harvesting: Heparin use

GÜL H. G., ERKURT M. A., SARICI A., KUKU İ., KAYA E., BERBER İ., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.60, sa.5, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.transci.2021.103240
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Anahtar Kelimeler: Stem cell harvesting, Mobilization, Heparin, G-CSF, Plerixafor, BONE-MARROW, MOBILIZATION, PHARMACOKINETICS, ANTAGONIST
  • İnönü Üniversitesi Adresli: Evet

Özet

Background and Objectives: Stem cell transplantation is a growing treatment strategy for most malignant and nonmalignant hematological diseases. Plerixafor and granulocyte colony stimulating factor (G-CSF) are usually used in mobilization regimens to increase the CD34+ cell count in the harvest. Heparin is a sulphated glycosaminoglycated polymer with 12-15 kDa mass. Heparin inhibits the CXCR4/SDF1 axis, as does plerixafor. In this study, our aim was to investigate the effect of using heparin on stem cell mobilization and harvesting.