Stress in couples undergoing assisted reproductive technology

TUNCAY G., YILDIZ S., KARAER A., Reyhani I., Ozgocer T., UÇAR C., ...Daha Fazla

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.301, sa.6, ss.1561-1567, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 301 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00404-020-05549-8
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1561-1567
  • Anahtar Kelimeler: Assisted reproductive technology, Salivary cortisol, Psychology, Stress, CORTISOL AWAKENING RESPONSE, INFERTILITY-RELATED STRESS, SALIVARY CORTISOL, WOMEN, PREGNANCY, PREDICTS, OUTCOMES, ANXIETY, RATIOS
  • İnönü Üniversitesi Adresli: Evet

Özet

Purpose To determine the associations between pre-treatment self-reported stress level, salivary cortisol levels, and clinical pregnancy outcome in couples undergoing assisted reproductive technology treatment (ART). Study design Seventy-five couples (150 patients) undergoing ART treatment were enrolled in this study. Psychological variables were assessed using the Perceived Stress Scale, Beck Anxiety Inventory, State-Trait Anxiety Inventory, and Beck Depression Inventory. Salivary cortisol levels were obtained from each couple prior to commencing gonadotropin treatment at several times (upon waking and at 15, 30, and 60 min after waking). Results There was no statistically significant association between the self-reported stress levels and the ART treatment outcome in couples. Women with a successful outcome after ART treatment had higher median salivary cortisol levels than women who had an unsuccessful result [24.7 (19.9-63.1) vs. 20.7 (10.4-30.4), respectively]. There was no statistically significant difference in the median salivary cortisol levels of men in relation to ART treatment outcome. Salivary cortisol levels of the couples were not correlated. Conclusions Women who had higher median salivary cortisol levels in the pre-treatment period had a higher clinical pregnancy rate. This result suggests that moderately increased activity of the hypothalamic-pituitary-adrenal axis during ART treatment might be associated with successful conception.