Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats


VARDI N. , PARLAKPINAR H. , ATEŞ B.

JOURNAL OF CHEMICAL NEUROANATOMY, cilt.43, ss.43-47, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 43 Konu: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.jchemneu.2011.09.003
  • Dergi Adı: JOURNAL OF CHEMICAL NEUROANATOMY
  • Sayfa Sayıları: ss.43-47

Özet

Several studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the various organs. Many agents have been tested experimentally to reduce or inhibit the oxidative stress. The aim of this study was to determine the possible protective effect of chlorogenic acid (CLG) on MTX-induced cerebellar damage in rats.