Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats

VARDI N., PARLAKPINAR H., ATEŞ B.

JOURNAL OF CHEMICAL NEUROANATOMY, cilt.43, sa.1, ss.43-47, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.jchemneu.2011.09.003
  • Dergi Adı: JOURNAL OF CHEMICAL NEUROANATOMY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-47
  • Anahtar Kelimeler: Purkinje cell, Caspase-3, Apoptosis, MTX, Rat, OXIDATIVE STRESS, CAFFEIC ACID, IN-VITRO, ANTIOXIDANT, APOPTOSIS
  • İnönü Üniversitesi Adresli: Evet

Özet

Several studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the various organs. Many agents have been tested experimentally to reduce or inhibit the oxidative stress. The aim of this study was to determine the possible protective effect of chlorogenic acid (CLG) on MTX-induced cerebellar damage in rats.