Association of Vitamin D Receptor Polymorphisms to Pulmonary Tuberculosis in Turkish Patients: An Up-to-date Meta-Analysis and A Case-Control Study

ACAR C., GÖZÜKARA BAĞ H. G., Vaizoğlu R. D.

Flora the Journal of Infectious Diseases and Clinical Microbiology, vol.26, no.3, pp.477-487, 2021 (ESCI, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5578/flora.20219716
  • Journal Name: Flora the Journal of Infectious Diseases and Clinical Microbiology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.477-487
  • Keywords: Tuberculosis, VDR polymorphisms, Genotyping, Vitamin D, Association study, GENE POLYMORPHISMS, IRANIAN PATIENTS, SUSCEPTIBILITY, VDR, NRAMP1, VARIANTS
  • Inonu University Affiliated: Yes

Abstract

Introduction: Tuberculosis is a major global health issue, threatening millions of lives every year. To understand the interactions between host and the pathogenic factors, many association studies are being held in different populations and most of the time results are controversial. Vitamin D receptor is one of the immunomodulatory molecules that may have an effect on susceptibility to tuber-culosis. Up to now, there was no positive association reported with the tuberculosis and Fok I or Taq I polymorphisms of VDR gene in tuberculosis patients of Turkish origin. The aim of this study was to make an updated meta-analysis and a case-control study in our group of patients for figuring out the association between Fok I and Taq I polymorphisms of VDR and TB.