Association of Vitamin D Receptor Polymorphisms to Pulmonary Tuberculosis in Turkish Patients: An Up-to-date Meta-Analysis and A Case-Control Study

ACAR C., GÖZÜKARA BAĞ H. G., Vaizoğlu R. D.

Flora the Journal of Infectious Diseases and Clinical Microbiology, cilt.26, sa.3, ss.477-487, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5578/flora.20219716
  • Dergi Adı: Flora the Journal of Infectious Diseases and Clinical Microbiology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.477-487
  • Anahtar Kelimeler: Tuberculosis, VDR polymorphisms, Genotyping, Vitamin D, Association study, GENE POLYMORPHISMS, IRANIAN PATIENTS, SUSCEPTIBILITY, VDR, NRAMP1, VARIANTS
  • İnönü Üniversitesi Adresli: Evet

Özet

Introduction: Tuberculosis is a major global health issue, threatening millions of lives every year. To understand the interactions between host and the pathogenic factors, many association studies are being held in different populations and most of the time results are controversial. Vitamin D receptor is one of the immunomodulatory molecules that may have an effect on susceptibility to tuber-culosis. Up to now, there was no positive association reported with the tuberculosis and Fok I or Taq I polymorphisms of VDR gene in tuberculosis patients of Turkish origin. The aim of this study was to make an updated meta-analysis and a case-control study in our group of patients for figuring out the association between Fok I and Taq I polymorphisms of VDR and TB.