Voltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode
ANALYTICAL AND BIOANALYTICAL ELECTROCHEMISTRY, cilt.12, sa.6, ss.857-869, 2020 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 6
- Basım Tarihi: 2020
- Dergi Adı: ANALYTICAL AND BIOANALYTICAL ELECTROCHEMISTRY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Arab World Research Source
- Sayfa Sayıları: ss.857-869
- İnönü Üniversitesi Adresli: Evet
Özet
Abstract- In the present study electrochemical detection of α-lipoic acid (α-LA) was carried
out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer
(BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry
method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide
and scanning electron microscopy (SEM) images. The number of cycles and scan rate effects
were studied using square wave voltammetry (SWV) in BR buffer containing 1 mM α-LA.
The electrochemical oxidation of α-lipoic acid on the modified Pt electrode is influenced by
the pH and it is an irreversible reaction in which one electron and one proton are transferred.
Electrolyte type and pH effect were studied. The anodic peak current shows a linear increase
with α-LA concentrations ranging from 0.03 mM to 2.00 mM at pH 5, the detection limit
being of 0.025 mM. The α-lipoic acid quantification in synthetic urine samples was made by
SWV with the modified Pt electrode.
Keywords- Square wave voltammetry; α-lipoic acid; Vanillin; Platinum electrode