Protective Role of Diospyros lotus L. in Cisplatin-Induced Cardiotoxicity: Cardiac Damage and Oxidative Stress in Rats

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BAŞAK TÜRKMEN N., Ozek D. A., TAŞLIDERE A., ÇİFTÇİ O., SARAL Ö., Gul C. C.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.19, sa.2, ss.132-137, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjps.galenos.2021.84555
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.132-137
  • Anahtar Kelimeler: Diospyros lotus, cisplatin, cardiotoxicity, oxidative stress, MOLECULAR-MECHANISMS, ELLAGIC ACID, CHEMOTHERAPY, ANTIOXIDANT, THERAPY, EXTRACT, TISSUE, LIVER, ASSAY
  • İnönü Üniversitesi Adresli: Evet

Özet

Objectives: Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by cisplatin through histological examination and oxidative stress parameters.