Protective effects of apocynin against ionizing radiation-induced hepatotoxicity in rats

Cagin Y. F., PARLAKPINAR H., VARDI N., Aksanyar S.

BIOTECHNIC & HISTOCHEMISTRY, cilt.97, sa.3, ss.228-235, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10520295.2021.1936641
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.228-235
  • Anahtar Kelimeler: Apocynin, hepatotoxicity, liver, oxidative stress, radiation, rats, INDUCED INTESTINAL DAMAGE, NADPH OXIDASE INHIBITOR, OXIDATIVE STRESS, LIPID-PEROXIDATION, ANTIOXIDANT RESPONSE, IRRADIATION, MELATONIN, LIVER, RADIOPROTECTION, GLUTATHIONE
  • İnönü Üniversitesi Adresli: Evet

Özet

Radiation hepatotoxicity is thought to be due to free oxygen radicals. We investigated the protective effects of apocynin (APO) against ionizing radiation induced oxidative stress in liver tissue following whole body ionizing radiation. We divided rats into four groups. The control group was injected intraperitoneally (i.p.) with saline for five consecutive days. A second group was injected i.p. with saline for 5 days and after 24 h, a single-dose of radiation (800 cGy) was administered to the whole abdomen. A third group was injected i.p. with 20 mg/kg APO for 5 days. A fourth group was injected i.p. with APO for 5 days and after 24 h, the rats were exposed to radiation. Ionizing radiation induced hepatotoxicity was demonstrated biochemically by significant changes in oxidative and antioxidant parameters. Our findings suggest that APO treatment may be protective against radiation induced hepatic injury by decreasing oxidative stress and increasing antioxidant activity.