Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis.

Harputluoglu, MUHSİN; Ozbek, M.; Demirel, U.; Otlu, BARIŞ; Yener, O.; Gursoy, N.; Tikici, D.; Erdogan, M.; Caliskan, A.; Dertli, R.

Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis.

Harputluoglu M. M. M., Ozbek M., Demirel U., Otlu B., Yener O., Gursoy N. C., ...Daha Fazla

Acta gastro-enterologica Belgica, cilt.82, sa.2, ss.285-290, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 82 Sayı: 2
Basım Tarihi: 2019
Dergi Adı: Acta gastro-enterologica Belgica
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.285-290
Anahtar Kelimeler: Mucosal immunity, inflammation, cytokines, acute pancreatitis, SPONTANEOUS BACTERIAL PERITONITIS, SYSTEMIC INFLAMMATORY RESPONSE, NOD2 GENE VARIANTS, INTESTINAL PERMEABILITY, CRITICALLY-ILL, ORGAN FAILURE, SERUM, POLYMORPHISMS, INTERLEUKIN-6, NOD2/CARD15
İnönü Üniversitesi Adresli: Evet

Özet

Background and aim : Intestinal bat tier dysfunction has been implicated in the development of infectious complications of acute pancreatitis. Nucleotide-Binding Oligomerization Domain- Containing Protein 2 (NOD2) plays an important role in the proper functioning of intestinal defense mechanisms. Here, we investigated the frequency of NOD2 variants in patients with mild and severe acute pancreatitis.