Synthesis of benzotriazole–amino acid–benzenesulfonamide conjugates and phenylsulfonyl-dipeptides

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Ezugwu J. A., Küçükbay H.

ARKIVOC, vol.4, pp.1-10, 2025 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2025
  • Doi Number: 10.24820/ark.5550190.p012.429
  • Journal Name: ARKIVOC
  • Journal Indexes: Scopus, Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
  • Page Numbers: pp.1-10
  • Open Archive Collection: AVESIS Open Access Collection
  • Inonu University Affiliated: Yes

Abstract

L-Amino acids were converted into sulfonamides by reaction with phenylsulfonyl chloride in a basic medium. Subsequent treatment of these sulfonamides with 1H-benzotriazole (BtH) and thionyl chloride at room temperature yielded benzotriazole–amino acid–benzenesulfonamide conjugates with yields ranging from 42% to 68%. Furthermore, the reaction of the benzotriazole derivatives with free glycine and free phenylalanine resulted in the formation of (phenylsulfonyl)dipeptides.