Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain

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Erdemli M. E., Aladag M. A., ALTINÖZ E., Demirtas S., TÜRKÖZ Y., Yigitcan B., ...More

NEUROTOXICOLOGY AND TERATOLOGY, vol.67, pp.37-43, 2018 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 67
• Publication Date: 2018
• Doi Number: 10.1016/j.ntt.2018.03.005
• Journal Name: NEUROTOXICOLOGY AND TERATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.37-43
• Keywords: Acrylamide, Oxidative stress, N-acetylcysteine, Fetal brain development, Brain-derived neurotrophic factor, N-ACETYLCYSTEINE, NEUROTROPHIC FACTOR, DIETARY-INTAKE, SUPPLEMENTATION, NEUROPROTECTION, NEUROGENESIS, EXPOSURE, CELLS, ACID, RATS
• Inonu University Affiliated: Yes

Abstract

Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity.