Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model

---

BATÇIOĞLU K., Yildirim B., SATILMIŞ B., UYUMLU A. B., GENÇ M. F., BENTLİ R., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.41, no.4, pp.275-279, 2016 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 41 Issue: 4
• Publication Date: 2016
• Doi Number: 10.1515/tjb-2016-0040
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.275-279
• Inonu University Affiliated: Yes

Abstract

Objective: Nitric oxide synthase and arginase are frequently antagonistic and interactive, although both use L-arginine as common substrate. Their balance is of potential functional importance. How the balance changes in cancer is unknown. Increasing evidence suggests that progression of carcinomas involves functional voltage-gated sodium channel (VGSC) activity.