Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model

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BATÇIOĞLU K., Yildirim B., SATILMIŞ B., UYUMLU A. B., GENÇ M. F., BENTLİ R., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.41, sa.4, ss.275-279, 2016 (SCI-Expanded, Scopus, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 41 Sayı: 4
• Basım Tarihi: 2016
• Doi Numarası: 10.1515/tjb-2016-0040
• Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.275-279
• İnönü Üniversitesi Adresli: Evet

Özet

Objective: Nitric oxide synthase and arginase are frequently antagonistic and interactive, although both use L-arginine as common substrate. Their balance is of potential functional importance. How the balance changes in cancer is unknown. Increasing evidence suggests that progression of carcinomas involves functional voltage-gated sodium channel (VGSC) activity.