Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model


BATÇIOĞLU K. , Yildirim B., SATILMIŞ B. , UYUMLU A. B. , GENÇ M. F. , BENTLİ R. , ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.41, ss.275-279, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/tjb-2016-0040
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.275-279

Özet

Objective: Nitric oxide synthase and arginase are frequently antagonistic and interactive, although both use L-arginine as common substrate. Their balance is of potential functional importance. How the balance changes in cancer is unknown. Increasing evidence suggests that progression of carcinomas involves functional voltage-gated sodium channel (VGSC) activity.