Purpose The aim of this study is to determine the relationship between the loneliness and depression levels of students studying at Inonu University, Faculty of Health Sciences, Departments of Nursing, Midwifery, Physiotherapy, Audiology and Child Development and the factors that affect these levels. Design and Methods This descriptive cross-sectional study which used a socio-demographic information form, the UCLA Loneliness Scale and the Beck Depression Inventory included 1004 students. Findings According to the results of the research, there was a positive relationship between loneliness and depression levels among university students. Class year, family type, place of residence, mother's education level, and economic situation were important indicators of loneliness and depression. Practice Implications Psychiatric nurses can help students express their psychological difficulties and help them change their behaviors and lifestyles.