Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.46, sa.9, ss.3709-3716, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 9
- Basım Tarihi: 2018
- Doi Numarası: 10.1177/0300060518777944
- Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.3709-3716
- Anahtar Kelimeler: NEDD4L, endometrial cancer, ubiquitin, tumorigenesis, endometrial hyperplasia, immunohistochemistry, NEDD4L EXPRESSION, DEGRADATION, PROGNOSIS, RECEPTOR, GENE
- İnönü Üniversitesi Adresli: Evet
Özet
Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.