Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

YILMAZ E., GÜL M., MELEKOĞLU R., İNCİ COŞKUN E., Sahin N., GÜL S., ...Daha Fazla

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.46, sa.9, ss.3709-3716, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 9
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0300060518777944
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3709-3716
  • Anahtar Kelimeler: NEDD4L, endometrial cancer, ubiquitin, tumorigenesis, endometrial hyperplasia, immunohistochemistry, NEDD4L EXPRESSION, DEGRADATION, PROGNOSIS, RECEPTOR, GENE
  • İnönü Üniversitesi Adresli: Evet

Özet

Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.