The regulatory role of dietary omega-3 essential fatty acids on oxidant/antioxidant balance in rat hippocampus

Sarsimaz M., Songur A., Kus I., Ozyurt B., Gulec M., Sogut S., ...Daha Fazla

NEUROSCIENCE RESEARCH COMMUNICATIONS, cilt.33, ss.114-123, 2003 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 33 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/nrc.10087
  • Sayfa Sayıları: ss.114-123


Omega-3 essential fatty acids (omega-3 EFA) contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. omega-3 EFA has been suggested to be protective against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in superoxide dismutase (SOD), xanthine oxidase (XO), malondialdehyde (MDA), and nitric oxide (NO) in the hippocampus of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 EFA were decapitated under ether anesthesia, and hippocampus was removed immediately.