Genetic and molecular characterization of uveal melanoma cell lines


Griewank K. G. , YU X., KHALİLİ J., Sozen M. M. , STEMPKE-HALE K., BERNATCHEZ C., ...Daha Fazla

PIGMENT CELL & MELANOMA RESEARCH, cilt.25, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.