Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

AYDOGAN, Hakan; GURLEK, Ali; Parlakpinar, HAKAN; ASKAR, Ibrahim; BAY-KARABULUT, Aysun; Aydogan, NİLAY; FARIZ, Alpay; Acet, HACI

doi:10.1016/j.bjps.2006.01.030

Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

Atıf İçin Kopyala

AYDOGAN H., GURLEK A., Parlakpinar H. , ASKAR I., BAY-KARABULUT A., Aydogan N. , ...Daha Fazla

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, cilt.60, ss.563-568, 2007 (SCI İndekslerine Giren Dergi)

Cilt numarası: 60 Konu: 5
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.bjps.2006.01.030
Dergi Adı: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
Sayfa Sayıları: ss.563-568

Özet

Background: Reperfusion injury is a phenomenon that occurs when tissues are subjected to ischaemia for a variable period of time, after which they are reperfused. Many factors have been implicated in the cause of reperfusion injury including free radicals and neutrophils. Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is an active component of propolis from honeybee; it has anti-inflammatory and immunomodulatory properties, and protective effects against ischaemia-reperfusion (I/R) injury. We investigated the effects of CAPE on the survival of skin flaps in the rat.