Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

AYDOGAN H., GURLEK A., Parlakpinar H., ASKAR I., BAY-KARABULUT A., Aydogan N., ...Daha Fazla

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, cilt.60, sa.5, ss.563-568, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.bjps.2006.01.030
  • Dergi Adı: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.563-568
  • Anahtar Kelimeler: caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), ischaemia-reperfusion injury, random pattern skin flap, NO-REFLOW PHENOMENON, SURVIVAL, CELLS, MODEL, INHIBITOR, MELATONIN, MUSCLE, DEXAMETHASONE, REDUCTION, RADICALS
  • İnönü Üniversitesi Adresli: Evet

Özet

Background: Reperfusion injury is a phenomenon that occurs when tissues are subjected to ischaemia for a variable period of time, after which they are reperfused. Many factors have been implicated in the cause of reperfusion injury including free radicals and neutrophils. Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is an active component of propolis from honeybee; it has anti-inflammatory and immunomodulatory properties, and protective effects against ischaemia-reperfusion (I/R) injury. We investigated the effects of CAPE on the survival of skin flaps in the rat.