Progressive Multifocal Leukoencephalopathy after Three Consecutive Liver Transplantations

ÖZDEMİR F., İNCE V., BAŞKIRAN A., ÖZDEMİR Z., BAYINDIR Y., OTLU B., ...Daha Fazla

INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, cilt.6, sa.3, ss.126-130, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 3
  • Basım Tarihi: 2015
  • Dergi Adı: INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.126-130
  • Anahtar Kelimeler: Liver transplantation, Leukoencephalopathy, progressive multifocal, JC virus, Immunocompromised host, Viral load, JC VIRUS, MYCOPHENOLATE-MOFETIL, COMPLICATIONS, RECIPIENTS, INFECTION, SURVIVAL
  • İnönü Üniversitesi Adresli: Evet

Özet

Progressive multifocal leukoencephalopathy (PML) is a lytic infection of the central nervous system caused by the reactivation of John Cunningham Virus (JCV) in severely immunosuppressed patients. Occurrence of PML after solid organ transplantations, especially after liver transplantation, is rare. If a patient has poor prognostic factors such as atypical radiological involvements or high viral load in cerebrospinal fluid (CSF), overall survival rates could be poor. Herein, we report on a patients who underwent liver transplantation three times and developed PML with unexpected radiological findings; he was also positive for JCV DNA with a high viral load. Although there are limited data about efficacy of cytarabine against JCV, it was given to the patient for five days. Despite the initiation of cytarabine and complete cessation of the immunosuppressive therapy, we lost the patient, unfortunately.