Biological Activities of NHC-Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents (dagger)

Al Nasr I., Touj N., Koko W., Khan T., ÖZDEMİR İ., YAŞAR S., ...Daha Fazla

CATALYSTS, cilt.10, sa.10, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/catal10101190
  • Dergi Adı: CATALYSTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, CAB Abstracts, Communication Abstracts, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: Pd(II)&#8211, N-heterocyclic carbene (NHC) complexes, benzimidazolium salts, biological activities, cytotoxicity, TETRANUCLEAR PALLADIUM(II) COMPLEXES, SUZUKI-MIYAURA, CARBENE-PD(II)-PPH3 COMPLEXES, CATALYTIC-ACTIVITIES, EFFICIENT CATALYST, COUPLING REACTIONS, CRYSTAL-STRUCTURES, PEPPSI COMPLEXES, MIZOROKI-HECK, COPPER FREE
  • İnönü Üniversitesi Adresli: Evet

Özet

N-heterocyclic carbene (NHC) precursors (2a-i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a-i) and palladium N-heterocyclic triphenylphosphines complexes (4a-i) were synthesized and characterized by elemental analysis and H-1 NMR, C-13 NMR, IR, and LC-MS spectroscopic techniques. The (NHC)Pd(II) complexes 3-4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites, and Vero cells in vitro. The biological assays indicated that all compounds are highly active against cancer cells, with an IC50 < 1.5 mu g mL(-1). Eight compounds proved antibacterial and antileishmanial activities, while only three compounds had strong antifungal activities against C. albicans. In our conclusion, compounds 3 (b, f, g, and h) and 4b are the most suitable drug candidates for anticancer, antimicrobial, and antiparasitical.