ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats


Cakir M., DÜZOVA H. , TEKİN S. , Taslidere E. , Kaya G. B. , ÇİĞREMİŞ Y. , ...Daha Fazla

LIFE SCIENCES, cilt.176, ss.10-20, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 176
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.lfs.2017.03.022
  • Dergi Adı: LIFE SCIENCES
  • Sayfa Sayıları: ss.10-20

Özet

Aim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA).