Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes

Touj N., Chakchouk-Mtibaa A., Mansour L., Harrath A. H., Al-Tamimi J., Mellouli L., ...Daha Fazla

JOURNAL OF MOLECULAR STRUCTURE, cilt.1181, ss.209-219, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1181
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.molstruc.2018.12.093
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.209-219
  • Anahtar Kelimeler: Copper-N-heterocyclic carbene complex, Benzimidazolium salts, Biological activities, CARBENE-SILVER(I) ACETATE COMPLEXES, ORGANOMETALLIC CHEMISTRY, COPPER(II) COMPLEXES, METAL-COMPLEXES, ANTICANCER, CATALYSTS, SILVER, ANTIBACTERIAL, CYTOTOXICITY, DERIVATIVES
  • İnönü Üniversitesi Adresli: Evet

Özet

New benzimidazolium salts (2) and their copper N-heterocyclic carbene complexes (3 4) were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and elemental analysis. All obtained complexes especially compounds 3d and 3e, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3b presents against S. aureus a MIC value of 0.0195 mg/ml quite similar to that of ampicillin (0.0195 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 3e presents an interesting AChEI activity with 32.80% of inhibition. (C) 2018 Published by Elsevier B.V.