Lycopene prevents experimental priapism against oxidative and nitrosative damage

ÇİFTÇİ O., OĞUZ F., BEYTUR A., Polat F., ALTINTAS R., OĞUZTÜRK H.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, sa.21, ss.3320-3325, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 21
  • Basım Tarihi: 2014
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3320-3325
  • Anahtar Kelimeler: Priapism, Lycopene, Oxidative stress, Nitrosative stress, Cavernosal tissue, NITRIC-OXIDE PRODUCTION, CHEMOTHERAPY, CANCER, ASSAY
  • İnönü Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Priapism is a persistent and often painful penile erection in the absence of sexual stimulation. It can cause progressive fibrosis, edema and drying of the erectile tissue and then it can lead to erectile dysfunction. Previous studies suggested that, neuronal nitric oxide levels increased during the priapism. High NO levels can result in the formation of reactive oxygen species (ROS) leading to oxidative stress in tissue and reproductive system. The aim of this study was to evaluate oxidative and nitrosative effects caused by priapism in cavernosal tissue and serum, and determinate beneficial effects of lycopene on ischemic priapism.