The effect of lidocaine on TRPM 2,6,7 and 8 channels in liver ischemia / reperfusion model in rats


Bilecik T., Ozozan O. V. , Coke H.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.11, no.4, pp.319-324, 2020 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.4328/acam.20075
  • Title of Journal : ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Page Numbers: pp.319-324

Abstract

Aim: The transient receptor potential melastatin (TRPM) channel is subfamilies of the transient receptor potential (TRP) channels, cation permeable channels. Ischemia and reperfusion (I / R) injury is a phenomenon highlighting cellular damage of the liver caused by oxygen. Lidocaine is a local anesthetic that blocks sodium channels and suppresses mitochondrial functions of neutrophils. In this study, we purpose to investigate the effects of TRPM2/8 and TRPM6/7 expressions after lidocaine treatment in liver ischemia/reperfusion rat model.