Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori

Mehmet N., Refik M., Harputluoglu M. M. M., Ersoy Y., Aydin N., Yildirim B.

MICROBIOLOGICA, cilt.27, sa.2, ss.139-148, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2004
  • Dergi Adı: MICROBIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.139-148
  • Anahtar Kelimeler: Helicobacter pylori, cytokines, nitrate, nitric oxide, gastritis, gastric ulcer, gastric cancer, NITRIC-OXIDE SYNTHASE, CANCER, EXPRESSION, INTERLEUKIN-8, ERADICATION, APOPTOSIS, STOMACH, MUCOSA, NITROTYROSINE, INFLAMMATION
  • İnönü Üniversitesi Adresli: Evet

Özet

This case control study presents data on the concentrations of nitrite and nitrate and a variety of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-2R (IL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor TNF-alpha in gastric fluid and serum. Patients with gastritis, gastric ulcer and gastric cancer are studied and grouped according to infection by Helicobacter pylori. The 208 patients who underwent tipper gastrointestinal endoscopic examination were classified as follows; H. pylori-positive gastritis (n=32), H. pylori-negative gastritis (n=32), H. pylori-positive ulcers (n=34), H. pylori-negative ulcers (n=34), 43 patients with H. pylori-positive gastric cancer in addition to 33 H. pylori-negative healthy control individuals. Gastric fluids and blood samples were taken concomitantly.