Protective Effects of Molsidomine Against Cisplatin-Induced Nephrotoxicity

KARAKOC H. T. E., Altintas R., PARLAKPINAR H., POLAT A., ŞAMDANCI E., SAGIR M., ...Daha Fazla

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.24, sa.4, ss.585-593, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.17219/acem/58970
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.585-593
  • Anahtar Kelimeler: cisplatin, molsidomine, kidney, rat, ISCHEMIA-REPERFUSION INJURY, INDUCED RENAL INJURY, NITRIC-OXIDE, OXIDATIVE STRESS, RADICAL SCAVENGER, REACTIVE OXYGEN, ANTIOXIDANT ENZYMES, HYDROGEN-PEROXIDE, L-ARGININE, IN-VITRO
  • İnönü Üniversitesi Adresli: Evet

Özet

Background. Cisplatin, an effective chemotherapeutic agent, is used for the treatment of several types of cancers. However, cisplatin has some severe side effects such as nephrotoxicity. On the other hand, molsidomine, a NO donor, has anti-oxidative and vasodilator effects.