The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-kappa B and Akt/VEGF signaling in CCl4-induced pancreas damage in rats

Aslan A., Beyaz S., Gok O., Can M. İ., Erman F., Erman O.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.43, sa.2, ss.145-152, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/08923973.2020.1869255
  • Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.145-152
  • Anahtar Kelimeler: Protein kinase B, B-cell lymphoma 2, ellagic acid, nuclear factor kappa B, pancreas damage, DIABETIC-NEPHROPATHY, CELLS, LUNG
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to evaluate the potential effect of ellagic acid (EA) in the treatment of pancreatic injury. EA has been found to have strong anti-inflammatory, antioxidative, and anticancer properties. The effects of EA on pancreatic star cell (PSC) activation and cell functions have been evaluated and it has been shown that it inhibits the activation of basic cell functions and PSCs and(.) it has antidiabetic activity through its effect on beta-pancreas cells.