Akademik Veri Yönetim Sistemi
The 11th International Mediterranean Symposium on Medicinal and Aromatic Plants, Rimini, İtalya, 6 - 08 Mayıs 2025, ss.96, (Özet Bildiri)
Artemisia L. genus is represented by 27 taxa, including 21 species, 3 subspecies and 3 varieties in Türkiye [1]. A. annua L. is a source of artemisinin and semi-synthetic artemisinin derivatives (dihydroartemisinin, artesunate etc.) included in the "Artemisinin-Based Combination Therapies (=ADCT)" for malaria treatment [2,3]. Chinese researcher Tu Youyou won the Nobel Prize in "Physiology or Medicine" for the discovery and purification of artemisinin and dihydroartemisinin [4]. In this study, the antioxidant activities of distilled water, ethanol, hexane and acetone extracts prepared with the aerial parts of A. absinthium L., A. annua L., A. abrotanum L., A. incana (L.) Druce and A. tournefortiana Rchb. were determined using four different methods (DPPH, CUPRAC, ABTS, FRAP). Additionally, the antimalarial activities of the same extracts against P. falciparum D6 and W2 strains were evaluated. In our antioxidant activity studies, A. annua was found to have the highest antioxidant capacity among the studied species. The ethanol extract of the A. annua, which had the lowest IC50 value (58.29μg/ml), showed the highest activity against DPPH radical. Besides this, the highest activity for all solvents used in the ABTS assay was A. annua; the lowest activity was seen in A. absinthium. In the CUPRAC method, the highest value measured is 150.35 mg GAE/g and belongs to the aqueous extract of the A. annua prepared by decoction. In vitro antimalarial activity study showed that the highest activity against both strains belonged to the hexane extracts of A. annua (IC50 values for D6 and W2 strains, 1861.8; 739.4, respectively). It was expected to observe high activity in A. annua which contains artemisinin. However, the fact that antimalarial activity has been detected in other species, albeit at very low levels, suggests that there may be other compounds responsible for the activity. Further analysis is required to detect these components.