This study aimed to determine children at risk of developmental difficulty by using a developmental monitoring tool during their hospital stay. The development of 113 hospitalised children aged 2-42 months was evaluated by using expressive and receptive language, fine and gross motor, social-emotional and relational functions, play, and self-help skills areas of the Guide for Monitoring Child Development (GMCD). There were 49 (42.4%) children with developmental difficulties. Developmental difficulty was found in 72.9% of the children of mothers who expressed a concern (p<0.001). Developmental difficulties were significantly more common in children of mothers without regular prenatal follow-up (p<0.001), with low educational level (p<0.001), and who had previously suffered stillbirth (p<0.013); and in children with a birth weight below 2500 g (p<0.002), and with consanguineous parents (p<0.007). The hospitalisation period is a good opportunity to identify children at risk of developmental problems and refer them for further assessment and early intervention.