Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma

FIRAT P. G. , Demirel E. E. , DEMİREL S. , DİKCİ S. , TÜRKÖZ Y. , Ozyalin F.

CURRENT EYE RESEARCH, cilt.44, ss.619-622, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/02713683.2019.1578378
  • Sayfa Sayıları: ss.619-622


Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.Patients and Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry.Results: A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls (p =0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels.Conclusion: The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.