Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma

FIRAT P. G., Demirel E. E., DEMİREL S., DİKCİ S., TÜRKÖZ Y., Ozyalin F.

CURRENT EYE RESEARCH, cilt.44, sa.6, ss.619-622, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/02713683.2019.1578378
  • Dergi Adı: CURRENT EYE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.619-622
  • Anahtar Kelimeler: Glaucoma, asymmetric dimethylarginine, symmetric dimethylarginine, L-arginine, NITRIC-OXIDE SYNTHASE, ASYMMETRIC DIMETHYLARGININE, EXFOLIATION SYNDROME, OXIDATIVE STRESS, DISEASE, MARKERS, SYSTEM, DAMAGE
  • İnönü Üniversitesi Adresli: Evet

Özet

Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.Patients and Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry.Results: A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls (p =0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels.Conclusion: The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.