Network rehabilitation and pipe material management could be shown as an important economic load for the Water Utility. For this reason, detailed analysis should be made and the worst regions should be determined before applying the methods. In this study, it is aimed to determine the priority regions for rehabilitation in distribution systems in order to prevent water losses. For this aim, a total of 28 factors that can be measured, applied and representing the problem were determined in the application area. Weight coefficients were calculated with the ENTROPY method to determine the degree of influence of these factors in decision making. The highest weight coefficient was obtained for the unreported leakages determined by active leakage control. ELCETRE I and PROMETHEE II methods were applied in determining the priority regions in rehabilitation. According to the results obtained with the ELECTRE I method, DMA 13, DMA 11, DMA 12, DMA 14 and DMA 5 regions were determined as the first 5 regions with rehabilitation priority. On the other hand, according to the PROMETHEE II method, the first 5 regions with rehabilitation priority were DMA 13, DMA 11, DMA 12, DMA 8 and DMA 15. When the results obtained by these two methods are compared, it is seen that the first region with priority of rehabilitation is similar. Thus, it is possible to provide a solution that requires investment priority and aims to increase water resource and economic efficiency. It is thought that the results obtained in this study will serve as a reference in terms of network and water loss management.