Protective effect of Lycium barbarum on renal injury induced by acute pancreatitis in rats

Dogan T., BATÇIOĞLU K., Kustepe E. K., UYUMLU A. B., YILMAZTEKİN Y.

PHARMACOGNOSY MAGAZINE, cilt.18, sa.77, ss.152-159, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 77
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4103/pm.pm_516_21
  • Dergi Adı: PHARMACOGNOSY MAGAZINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.152-159
  • Anahtar Kelimeler: <p>Acute pancreatitis</p>, antioxidant enzymes, kidney Injury, Lycium barbarum, oxidative stress, OXIDATIVE STRESS, GLUTATHIONE-PEROXIDASE, INFLAMMATORY-RESPONSE, LIPID-PEROXIDATION, DNA-DAMAGE, POLYSACCHARIDES, CYTOKINES, LIVER, COMPLICATIONS, PATHOPHYSIOLOGY
  • İnönü Üniversitesi Adresli: Evet

Özet

Background: Lycium barbarum (LB) is a plant species that is well known in Chinese traditional medicine and is also considered a nutrient, belonging to the Solanaceae family, also called goji berry or wolfberry. Objectives: The aim of this study was to investigate the protective efficacy of LB, in kidney damage caused by acute pancreatitis (AP). Materials and Methods: In the study, we used 36 female Wistar albino rats (12 in each group) which were divided into three groups: Control, cerulein (100 mu g/kg b. wt. intraperitonally) and Cerulein + LB (6 mg/ml/day gastric gavage) group. Serum lipase, Interleukin (IL)-1, and IL-6 levels were measured. Superoxide dismutase, catalase (CAT), glutathione peroxidase enzyme activity assays and 8-hydroxy deoxyguanosine, malondialdehyde (MDA), and protein levels were measured in kidney tissue samples. In addition, histopathological analysis was performed in kidney tissue samples. Results: According to the findings, in the AP model created with Cerulein, administration of LB plant extract decreased oxidative stress and damage caused by AP in the kidney tissue and partially suppressed the inflammatory reactions in the tissue. Conclusion: According to the findings, in the AP model created with Cerulein, administration of LB extract decreased oxidative stress and in kidney damage caused by AP.