Akademik Veri Yönetim Sistemi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.121, ss.108289, 2026 (SCI-Expanded, Scopus)
Eudragit S100 (ES100) is a pH-sensitive polymer that remains stable in acidic media but dissolves at intestinal
pH, and its responsiveness can be further tuned by controlling fber morphology and incorporating hydrophilic
components. Here, ES100-based electrospun fbers with tailored morphology and architecture were developed
for colon-targeted applications. Randomly oriented and aligned fbers were fabricated using binary solvent
systems of ethanol (EtOH) or methanol (MeOH) combined with dimethylformamide (DMF) or N,Ndimethylacetamide (DMAc) at ratios of 6:4–8:2. Core–shell nanofbers were obtained using pectin (Pct) as the
core. Morphology, structure, and mechanical properties were characterized by SEM, XRD, DSC, and tensile
analysis, while swelling/dissolution behavior and pH-responsive release of methylene blue (MB) as a model
compound were evaluated at pH 1.2, 6.8, and 7.4. Variations in polymer concentration and solvent composition
yielded smooth nano-to micron-sized fbers exhibiting cylindrical to ribbon-like morphologies. Alignment
markedly increased tensile strength in microfbers, while elongation at break remained comparably high for both
aligned nano- and microfbers. Swelling, dissolution, and release behavior were governed by fber diameter,
alignment, and composition: thinner, randomly oriented fbers swelled and degraded faster, whereas thicker or
aligned fbers demonstrated greater resistance. All samples showed minimal release at pH 1.2, confrming gastric
protection. At pH 6.8, aligned fbers exhibited the lowest release, followed by core–shell fbers, while randomly
oriented fbers showed higher release. At pH 7.4, all fbers rapidly disintegrated and released most of the MB
within 2 h. These results highlight the potential of architecture-tailored ES100 fbers for colon-targeted delivery.