Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?

Özdemir, RAMAZAN; Gökce, İSMAİL; Taşlıdere, ASLI; Tanbek, KEVSER; Gul, Cemile; Sandal, SÜLEYMAN; Turgut, HATİCE; Kaya, HÜSEYİN; Aslan, MEHMET

doi:10.1016/j.intimp.2021.108033

Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?

Özdemir R., Gökce İ. K., Taşlıdere A., Tanbek K., Gul C. C., Sandal S., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.99, 2021 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 99
Publication Date: 2021
Doi Number: 10.1016/j.intimp.2021.108033
Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Keywords: Bronchopulmonary Dysplasia, Chronic Lung Disease, Chrysin, Newborn, Antioxidant, Antiinflammatory, Hyperoxia-Induced Lung Injury, BRONCHOPULMONARY DYSPLASIA, OXIDATIVE STRESS, INFLAMMATION, PROTECTS, RATS, MICE
Inonu University Affiliated: Yes

Abstract

Background: Oxidative stress and inflammation play a critical role in the etiopathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study was to evaluate the preventive effect of Chrysin (CH), an antioxidant, antiinflammatory, antiapoptotic and antifibrotic drug, on hyperoxia-induced lung injury in a neonatal rat model.