Determination of characterization, antibacterial and drug release properties of POSS- based film synthesized with sol-gel technique

Acari I. K., KÖYTEPE S., ATEŞ B., YILMAZ İ., SEÇKİN T.

TURKISH JOURNAL OF CHEMISTRY, cilt.45, sa.6, ss.1774-1785, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/kim-2101-56
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1774-1785
  • Anahtar Kelimeler: Polyhedral oligomeric silsesquioxane, dip coating, antibacterial activity, drug delivery, POLYHEDRAL OLIGOMERIC SILSESQUIOXANE, METRONIDAZOLE, DELIVERY, DESIGN, NANOPARTICLES, PARAMETERS, POLYMERS
  • İnönü Üniversitesi Adresli: Evet

Özet

the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h. As a result, it is thought that the synthesized film will be a good candidate especially for biomedical surface coating areas.