The Effects of Colistin on Imipenem MICs in OXA-48 Producing Klebsiella pneumoniae Isolates: An In-Vitro Study
Mediterranean Journal of Infection Microbes and Antimicrobials, cilt.10, sa.1, ss.1-7, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/mjima.galenos.2020.2021.2
- Dergi Adı: Mediterranean Journal of Infection Microbes and Antimicrobials
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.1-7
- Anahtar Kelimeler: Colistin, imipenem, combination, Klebsiella pneumoniae, OXA-48
- İnönü Üniversitesi Adresli: Evet
Özet
Introduction: A new approach to carbapenem resistance-K. pneumoniae infections is to use combination drug therapies. However, little data are available about the effectiveness of the in vitro carbapenem plus colistin combination against oxacillinase-48 (OXA-48) producing K. pneumoniae. Therefore, the aim of this study is to assess the potential synergistic activity of imipenem plus colistin in OXA-48-producing K. pneumoniae strains and investigate the changes in the imipenem minimal inhibitory concentrations (MICs) to varying MICs of colistin.