The Effects of Colistin on Imipenem MICs in OXA-48 Producing Klebsiella pneumoniae Isolates: An In-Vitro Study

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Atıf İçin Kopyala

Duman Y., Tekerekoğlu M. S., Kuzucu Ç., Yakupoğulları Y.

Mediterranean Journal of Infection Microbes and Antimicrobials, cilt.10, sa.1, ss.1-7, 2021 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 10 Sayı: 1
• Basım Tarihi: 2021
• Doi Numarası: 10.4274/mjima.galenos.2020.2021.2
• Dergi Adı: Mediterranean Journal of Infection Microbes and Antimicrobials
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
• Sayfa Sayıları: ss.1-7
• Anahtar Kelimeler: Colistin, imipenem, combination, Klebsiella pneumoniae, OXA-48
• İnönü Üniversitesi Adresli: Evet

Özet

Introduction: A new approach to carbapenem resistance-K. pneumoniae infections is to use combination drug therapies. However, little data are available about the effectiveness of the in vitro carbapenem plus colistin combination against oxacillinase-48 (OXA-48) producing K. pneumoniae. Therefore, the aim of this study is to assess the potential synergistic activity of imipenem plus colistin in OXA-48-producing K. pneumoniae strains and investigate the changes in the imipenem minimal inhibitory concentrations (MICs) to varying MICs of colistin.