The roles of thiol oxidoreductases in yeast replicative aging


Hacioglu E., Esmer I., Fomenko D. E. , Gladyshev V. N. , Koc A.

MECHANISMS OF AGEING AND DEVELOPMENT, vol.131, pp.692-699, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131
  • Publication Date: 2010
  • Doi Number: 10.1016/j.mad.2010.09.006
  • Title of Journal : MECHANISMS OF AGEING AND DEVELOPMENT
  • Page Numbers: pp.692-699
  • Keywords: Oxidoreductase, Antioxidant, Oxidation, Yeast, Aging, Life span, SACCHAROMYCES-CEREVISIAE, OXIDATIVE STRESS, LIFE-SPAN, THIOREDOXIN REDUCTASE, ENDOPLASMIC-RETICULUM, CHAPERONE PROTEINS, GENES, IDENTIFICATION, PEROXIREDOXIN, PROTECTION

Abstract

Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.