The roles of thiol oxidoreductases in yeast replicative aging
MECHANISMS OF AGEING AND DEVELOPMENT, vol.131, pp.692-699, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 131
- Publication Date: 2010
- Doi Number: 10.1016/j.mad.2010.09.006
- Journal Name: MECHANISMS OF AGEING AND DEVELOPMENT
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.692-699
- Keywords: Oxidoreductase, Antioxidant, Oxidation, Yeast, Aging, Life span, SACCHAROMYCES-CEREVISIAE, OXIDATIVE STRESS, LIFE-SPAN, THIOREDOXIN REDUCTASE, ENDOPLASMIC-RETICULUM, CHAPERONE PROTEINS, GENES, IDENTIFICATION, PEROXIREDOXIN, PROTECTION
- Inonu University Affiliated: No
Abstract
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.