Akademik Veri Yönetim Sistemi
6th Organic Chemistry Congress, Eskişehir, Türkiye, 10 - 13 Eylül 2025, ss.40, (Özet Bildiri)
Benzimidazolium refers to the protonated form or quaternized derivatives of benzimidazole, a bicyclic aromatic heterocycle consisting of a benzene ring fused with an imidazole ring. Benzimidazolium salts, typically formed by quaternization at the nitrogen atoms or by protonation under acidic conditions, have attracted significant interest due to their diverse biological activities, including antimicrobial, antiviral, anticancer, and anti-inflammatory properties [1-4]. These biological effects are often attributed to their ability to interact with biomolecular targets such as DNA, enzymes, or cell membranes, thereby disrupting cellular functions. Benzimidazolium-based compounds have also shown promising antiparasitic activities and are being investigated for drug delivery and catalytic applications due to their chemical stability and ability to form ionic liquids [5-8]. Additionally, some benzimidazolium salts are considered as potential anticancer agents because of their capacity to induce apoptosis and inhibit topoisomerase enzymes in cancer cells [9]. Their structural flexibility allows for the introduction of various substituents, enhancing pharmacological efficacy and selectivity. In this study, benzimidazolium salts bearing various functional groups were synthesized. The structures of the newly synthesized benzimidazolium salts were elucidated using appropriate spectroscopic techniques, including NMR and FT IR. The anticancer activities of these compounds were evaluated against HCT166 (colon cancer) cell lines. The results demonstrated that benzimidazolium salts containing the 4-benzyloxybenzyl (4), fluorinated and benzoyl (3) groups exhibited higher efficacy than the standard drug, cisplatin.